Fig. 1: Stratification of PTC based on 329 DMRs. | npj Precision Oncology

Fig. 1: Stratification of PTC based on 329 DMRs.

From: Epigenomic profiling of papillary thyroid carcinoma reveals distinct subtypes with clinical implications

Fig. 1

Heatmap of differential DNA methylation levels across 329 DMRs in our cohort (A) and TCGA cohort (B). The DNA methylation levels of each tumor sample were normalized by subtracting the DNA methylation levels of paired normal tissues. Hypermethylation and hypomethylation were defined based on the DNA methylation levels in each subgroup. C PCA of our PTC cohort conducted with 329 DMRs. D Correlation plot of DNA methylation levels of 329 DMRs between DNA methylation subgroups of each cohort. The correlation coefficients of hypermethylated and hypomethylated CpG islands were separately calculated. E Overall survival analysis of DNA methylation of TCGA PTC cohort. Statistical significance was calculated using the log-rank test.

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