Fig. 4: Differential chromatin accessibility and its association with gene expression in PTC methylation subgroups. | npj Precision Oncology

Fig. 4: Differential chromatin accessibility and its association with gene expression in PTC methylation subgroups.

From: Epigenomic profiling of papillary thyroid carcinoma reveals distinct subtypes with clinical implications

Fig. 4

A Dot plot illustrating genes with differential methylation and expression levels of PTC1 and PTC2 across our cohort and TCGA cohort. Red dots indicate differentially methylated and expressed genes between PTC1 and PTC2 in our cohort and TCGA cohort, respectively. B Classification of patients based on the expression profile of 77 genes shortlisted in Fig. 4A, comparing TCGA (left) and GSE162515 (right) cohorts. Gene ontology analyses for genes near regions of increased (C) and decreased (D) chromatin accessibility.

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