Fig. 4: Immune-evasive phenotype of the tumor microenvironment of HER2-low TNBC.
From: Epigenetic determinants of an immune-evasive phenotype in HER2-low triple-negative breast cancer
a Boxplots representing significant differences in the composition of TME immune cells. HER2-zero TNBC is shown in purple and HER2-low in turquoise. Statistical differences are represented as *P < 0.05, **P < 0.01. b Boxplots showing the immune and stroma scores. Scores were calculated using the xCell algorithm. HER2-zero TNBC is shown in purple and HER2-low in turquoise. The Wilcoxon rank-sum test was used to test statistical differences, which are represented as **P < 0.01; ns non-significant differences. TNBC triple-negative breast cancer, TME tumor microenvironment, aDC activated dendritic cells, CD8+ Tcm CD8+ central memory T-cells, Csm B-cells Class-switched memory B-cells, Th2 cells Type 2 T-helper cells.
