Fig. 1: Comprehensive molecular characterization of TMB-high BCs.

a Schematic representation of the percentage of TMB-high BCs in the MSK-IMPACT clinical sequencing cohort. Bar chart depicts the mean TMB among the two respective groups. b Bar chart showing the TMB distribution across the cohort with the corresponding proportion of tumors. c Oncoprint depicting the repertoire of gene alterations in the study cohort by the targeted MSK-IMPACT platform, sorted by decreasing frequency. The top 10 most frequently altered genes are presented, in addition to select genes of clinical importance. Tumors are shown in columns and genes in rows, with the percentage of alterations displayed on the right. d Distribution of common metastatic sites sequenced within the cohort with corresponding alteration frequency of select genes. Alteration legend is the same as in 1c. The icon of the human figure is created in https://BioRender.com. Abbreviations: Cerebrospinal fluid (CSF); Gynecologic tract (GYN tract). e Bar chart demonstrating the percentage of CD274 amplification in TMB-high and non-TMB-high BCs. f Circos plot summarizing the distribution of fusions in TMB-high BCs. Inter and intrachromosomal translocations are marked by the colored lines. The numeric digits signify the chromosome number of the corresponding event.