Fig. 4: TMB-high BCs harbor an increased percentage of alterations pertaining to DDR.
From: Genomic characterization of tumor mutational burden-high breast carcinomas
a Distribution of all (left panel) and driver (right panel) DDR gene alterations in TMB-high BCs (red) and non-TMB-high BCs (blue). Abbreviations: Mismatch repair (MMR); Nucleotide excision repair (NER); Homologous recombination (HR); Fanconi anemia (FA); Miscellaneous (Misc.). Schematic representation depicting the protein domain(s) with likely oncogenic hotspot mutations in b RAD51C and c POLE. The mutation frequency is represented by the height of each lollipop (y-axis). Green circles: missense or in-frame mutations; Black circles: truncating or splice site mutations; Arrows: hotspot mutations.
