Fig. 5: Genomic alterations identified in TMB-high TNBCs.
From: Genomic characterization of tumor mutational burden-high breast carcinomas
a Oncoprints displaying select genetic alterations present in primary and metastatic TMB-high TNBCs. Primary and metastatic tumors from the same patient are annotated by the black and white circles. b Box plot (left panel) demonstrating the distribution of TILs in primary TMB-high TNBCs (n = 22) according to the International TILs Working Group recommendations. Mean value is demonstrated, and quartile calculation is inclusive of the median. Representative H&E-stained photomicrographs of primary TMB-high TNBCs (right panel) with a prominent lymphocytic infiltrate are shown. Scale bars, 100 μm. c Stacked box plots collectively showing copy number alterations assessed by FACETS in tumors with co-occurring loss-of-function (≥ 3) mutations in specific genes. Abbreviation: Whole genome duplication (WGD).
