Fig. 2: Baseline radiosensitivity of cell types used for ACT.
From: Enhancing adoptive cell therapy: future strategies for immune cell radioprotection in neuro-oncology
This figure summarizes the inherent radiosensitivity and other effects of irradiation on various immune-cell types commonly used in adoptive cell therapy (ACT). While radiosensitivity is likely highly context-dependent, in general B cells are highly sensitive to radiation and undergo apoptosis at even low doses. T cells are sensitive, with sublethal doses (<2 Gy) causing activation, while higher doses (>2 Gy) induce apoptosis. γδ T cells are relatively resistant to radiation and maintain their cytotoxic functions. Invariant natural killer T cells (iNKT cells) exhibit moderate resistance to radiation. Natural killer (NK) cells and macrophages are relatively radioresistant.
