Fig. 7: Formulation of radioresistant CAR T cells.
From: Enhancing adoptive cell therapy: future strategies for immune cell radioprotection in neuro-oncology
CAR T cells are developed from peripheral blood mononuclear cells (PBMCs) which are harvested, expanded, sorted into T cells, and then tranduced with lentiviral vectors to deliver the CAR gene playload. Our proposal will identify the most potent radioprotector genes to deliver in a similar fashion during the CAR T manufacturing process, producing radioresistant CAR T cells.
