Fig. 1: SPP1 promotes the progression of NF1-associated tumors in the peripheral and central nervous systems. | npj Precision Oncology

Fig. 1: SPP1 promotes the progression of NF1-associated tumors in the peripheral and central nervous systems.

From: Natural history of SPP1 signaling in NF1 tumors

Fig. 1

A Normalized SPP1 expression from bulk RNA-seq of human cNFs, pNFs and MPNSTs. B Spp1 knockout expands the survival of spontaneous MPNST mouse models. C Human LGG dataset shows survival stratification between SPP1high and SPP1low groups. D LGG patients with NF1 truncating mutation have significantly higher expression of SPP1. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Back to article page