Fig. 2: SPP1-CD44 signaling is enriched in the stem-like SCL populations. | npj Precision Oncology

Fig. 2: SPP1-CD44 signaling is enriched in the stem-like SCL populations.

From: Natural history of SPP1 signaling in NF1 tumors

Fig. 2

A scRNAseq clusters of integrated human pNFs in UMAP. B UMAP plot of SPP1 expression in pNFs. The blue arrow indicates the SCP-like cluster. C Subclustering shows different cell clusters from the SCL in pNFs. D Dot plots of SPP1, CD44, NES and ERBB3 expression in pNF SCL clusters. E scRNAseq clusters of integrated human MPNSTs in UMAP. F UMAP plot of SPP1 expression in MPNSTs. The blue arrow indicates the SCP-like cluster, and the yellow arrow indicates the macrophage cluster. G Subclustering shows different cell clusters from the SCL in MPNSTs. H Dot plots of SPP1, CD44, NES and ERBB3 expression in MPNST SCL clusters. MES Mesenchymal; NC neural crest.

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