Fig. 4: SPP1 signaling dynamics in NF1 tumor progression. | npj Precision Oncology

Fig. 4: SPP1 signaling dynamics in NF1 tumor progression.

From: Natural history of SPP1 signaling in NF1 tumors

Fig. 4

A CellChat-based signaling comparison between pNFs and MPNSTs. Information flow represents the sum of communication probabilities between all pairs of cell clusters in each signaling pathway. B SPP1-CD44 signaling in pNFs (only cell types with significant signaling interactions are shown in the heatmap). Clusters with significant SPP1 expression were labeled as Sender (green framed), and clusters with significant CD44 expression were labeled as receiver (blue framed). C SPP1-CD44 communications in MPNSTs. The top bar graphs in each heatmap show the total incoming signaling strength for each cluster while the bar graphs on the right show total outgoing signaling strength for each cluster.

Back to article page