Fig. 5: Nes-positive SCL clusters enrich Spp1 expression in scRNAseq data of two-month-old dorsal root ganglia from DhhCreNF1f/f mice and controls. | npj Precision Oncology

Fig. 5: Nes-positive SCL clusters enrich Spp1 expression in scRNAseq data of two-month-old dorsal root ganglia from DhhCreNF1f/f mice and controls.

From: Natural history of SPP1 signaling in NF1 tumors

Fig. 5

A UMAP representation of the integrated two-month-old pre-tumor and age-matched control DRGs. B Spp1 and C Nes expression is enriched in SCL-1 and SCL-2 (green circles) in pre-tumor DRGs. D CellChat-based signaling comparison between the pre-tumor and control. SPP1 signaling is indicated by the red arrow. E SPP1-CD44 communication in pre-tumor microenvironment. Clusters with significant Spp1 expression were labeled as Sender (green framed), and clusters with significant Cd44 expression were labeled as Receiver (blue framed). Cd44 Spp1 F Comparison of Spp1 expression in the SCL clusters between pre-tumor and control DRGs. Wilcoxon Rank Sum Test (*p < 0.05, ****p < 0.0001).

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