Fig. 6: pNF spatial transcriptome reveals the autocrine and paracrine of SPP1-CD44 signaling in TME. | npj Precision Oncology

Fig. 6: pNF spatial transcriptome reveals the autocrine and paracrine of SPP1-CD44 signaling in TME.

From: Natural history of SPP1 signaling in NF1 tumors

Fig. 6

A SPP1 expression in pNF tissue. B Deconvolution of the spatial transcriptome using scRNAseq signatures in the selected tissue area. Turquoise and yellow circles indicate selected spots with dominant SCP-like and MAC-2 expressions, respectively. C SCP-like enriched spatial spots. D MAC-2 enriched spatial spots. E SPP1, F NES, G ERBB3, and H CD44 expression in the spatial analysis.

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