Fig. 4: Metastatic LNs are occupied by unique CD8 T cell phenotypes. | npj Precision Oncology

Fig. 4: Metastatic LNs are occupied by unique CD8 T cell phenotypes.

From: APOE-high myeloid cells are uniquely associated with metastatic intrathoracic lymph nodes obtained by EBUS-TBNA in primary lung cancer

Fig. 4

A Volcano plot illustrating differential gene expression in CD8 T cells between metastatic LN and control LN groups. B Enriched CD8 T cell pathways in the metastatic LN group as compared to controls. C Dot plot categorized by functional groups in CD8 T cells showing the differential expression of select genes between control and metastatic LN groups. D Violin plot demonstrating percentages of CD103 (ITGAE) positive CD8 T cells between control and metastatic LN groups from CyTOF data. Additionally, the percentage of PD1, TIGIT, TIM3 and CTLA4 positive cells among CD103 + CD8 T cells was compared between the two groups. Statistical significance was determined by Mann-Whitney test (**p < 0.01, *p < 0.05).

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