Fig. 5: APOE-high myeloid cells and CD8 T cells exhibit enhanced cell-cell interactions in metastatic LNs. | npj Precision Oncology

Fig. 5: APOE-high myeloid cells and CD8 T cells exhibit enhanced cell-cell interactions in metastatic LNs.

From: APOE-high myeloid cells are uniquely associated with metastatic intrathoracic lymph nodes obtained by EBUS-TBNA in primary lung cancer

Fig. 5

A A network model illustrating the cell-cell interactions among immune cell types and the differential interaction strength between control LN and metastatic LN groups. The nodes and edges represent the immune cell types and the interactions between the cell types, respectively. Red and blue edges represent upregulated and downregulated interactions, respectively, in the metastatic LN group compared to control LN group. The thickness of the edge is indicative of the strength of the interaction. B A heatmap depicting the relationship among immune cells. The rows represent outgoing interactions from the corresponding immune cell type, while the columns represent incoming interactions received by the corresponding immune cell type. The color gradient represents the strength of the interaction. The colors red and blue indicate and increase and decrease, respectively, in interaction strength in the metastatic LN group compared to control LN group. C Scatter plot showing changes in the strength of incoming and outgoing interactions for each cell type in metastatic LN compared to control LN groups. D Heatmaps displaying signal pathway networks of SPP1 and FN1 in the metastatic LN group. E Heatmaps displaying signal pathway networks of MIF and GALECTIN in the control and metastatic LN groups.

Back to article page