Fig. 3: Comparative analysis of cell communication networks in BCG naïve and recurrent samples. | npj Precision Oncology

Fig. 3: Comparative analysis of cell communication networks in BCG naïve and recurrent samples.

From: Single-cell RNA-sequencing of BCG naïve and recurrent non-muscle invasive bladder cancer reveals a CD6/ALCAM-mediated immune-suppressive pathway

Fig. 3

A The differences in the numbers of cell-to-cell interactions predicted by CellChat for naïve and recurrent samples are plotted. Red arrows indicate increased interactions in recurrent samples. Blue arrows indicate decreased interactions in recurrent samples. The thickness of the connecting lines relates to the number of differential interactions, with the largest changes in either direction labeled with exact numbers. B Summary plot of enriched interactions between T cells and urothelial cells (aggregate of T cells-to-Urothelial and Urothelial-to-T cells interactions from Supplementary Fig. S4A) in recurrent samples compared to naïve. C Heatmaps of CD6-ALCAM communication probability score between cell types in naïve (left) and recurrent (right) samples. D Fraction of CD6hi cells in each T cell population in naïve (green) and recurrence (red) samples. The asterisk indicates statistical significance (Mann Whitney U test, Benjamini-Hochberg-adjusted p = 0.018). E Time to disease recurrence post-BCG treatment for Jong et al. NMIBC cohort (n = 282), stratified by median CD6/ALCAM dual gene signature score. P-value was derived from log-rank test.

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