Fig. 5: Spatial determination of CNV status to identify clonal events in the TNBC tumor. | npj Precision Oncology

Fig. 5: Spatial determination of CNV status to identify clonal events in the TNBC tumor.

From: Computational pathology annotation enhances the resolution and interpretation of breast cancer spatial transcriptomics data

Fig. 5

Spatial visualization of tumor clones on the BCSA1 TumA1 and TumB1 sections using spots with at least 50% (a), 70% (c), and 90% (e) of tumor purity defined by CTA. Genome-wide CNV analysis for each spot with at least 50% (b), 70% (d), and 90% (f) of tumor cell fractions. The color indicates scaled expression levels, with blue representing copy number loss and red indicating copy number gain. Clonal grouping of spots was defined by hierarchical clustering. The chromosome numbers are displayed at the bottom of the heatmap.

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