Fig. 2

Mapping DNA methylation with graphene nanopores. Recorded ionic current traces through a 5 nm graphene nanopore for mDNA-MBD1 complexes with a single MBD protein/methylation site present in three different positions: a 20^th, b 60^th, and c 100^th bp in a 120 bps mDNA (shown schematically on the right panel). The thick lines represent the moving average with a window of 1 ns. The yellow rectangles highlight the time duration when the MB1 protein resides in the pore and the arrows denote the time instant when the complex leaves the pore