Table 1 Fourteen neurocognitive assessments covering five cognitive domains and dexterity were performed by a neuropsychologist. Shown are the group mean and standard deviation, range of score, and the correlation between each test and the cross-validated prediction constructed from the digital biomarkers for that test
Cognitive predictions | |||
|---|---|---|---|
Mean (SD) | Range | R (predicted), p-value | |
Working memory | |||
Digits forward | 10.9 (2.7) | 7–15 | 0.71 ± 0.10, 10−4 |
Digits backward | 8.3 (2.7) | 4–14 | 0.75 ± 0.08, 10−5 |
Executive function | |||
Trail A | 23.0 (7.6) | 12–39 | 0.70 ± 0.10, 10−4 |
Trail B | 53.3 (13.1) | 37–88 | 0.82 ± 0.06, 10−6 |
Symbol digit modality | 55.8 (7.7) | 43–67 | 0.70 ± 0.10, 10−4 |
Language | |||
Animal fluency | 22.5 (3.8) | 15–30 | 0.67 ± 0.11, 10−4 |
FAS phonemic fluency | 42 (7.1) | 27–52 | 0.63 ± 0.12, 10−3 |
Dexterity | |||
Grooved pegboard test (dominant hand) | 62.7 (6.7) | 51–75 | 0.73 ± 0.09, 10−4 |
Memory | |||
California verbal learning test (delayed free recall) | 14.1 (1.9) | 9–16 | 0.62 ± 0.12, 10−3 |
WMS-III logical memory (delayed free recall) | 29.4 (6.2) | 18–42 | 0.81 ± 0.07, 10−6 |
Brief visuospatial memory test (delayed free recall) | 10.2 (1.8) | 5–12 | 0.77 ± 0.08, 10−5 |
Intelligence scale | |||
WAIS-IV block design | 46.1(12.8) | 12–61 | 0.83 ± 0.06, 10−6 |
WAIS-IV matrix reasoning | 22.1(3.3) | 12–26 | 0.80 ± 0.07, 10−6 |
WAIS-IV vocabulary | 40.6(4.0) | 31–50 | 0.67 ± 0.11, 10−4 |
