Table 1 List of sensors and their respective domains and metrics

From: Digital biomarkers for Alzheimer’s disease: the mobile/wearable devices opportunity

Sensor

Metrics

Sense—Domain

Reference

Camera

Saccades, saccades in reading

Occulomotor—eye movements

5, 30,31,– 32

 

Novelty preference

Occulomotor—eye movements

22, 27

 

Constriction reflex in response to stimuli

Occulomotor—pupillary response

12, 23, 29

 

Multiple face features

Behavior—facial expressions

 

Microphone

Voice power spectrum and tremor

Speech and language—voice features

 
 

Vocabulary, syntactic and semantic qualities, pauses, others

Speech and language—cognition

7, 18,19,– 20

 

Ambient noise level—dominant frequencies

Environment

 

Accel/gyro

Gait metrics, distance, steps, symmetry, etc

Movement—gross motor

 
 

Other activity metrics (bike, swim, run, etc)

 

6,7,8,9,– 10

 

Overall activity level—energy consumption

 

79, 84

 

Tremor

Movement—fine motor

9, 13,14,15,16,– 17

Barometer

Gait/climb information

Movement—gross motor

 
 

Barometric pressure

Environment

 

Touchscreen

Swipe pattern efficiency

Movement—fine motor

 
 

Keyboard typing/tapping speed

 

9, 13,14,15,16,– 17

 

Vocabulary, syntactic, and semantic qualities

Speech and Language—written text

 

Geoposition

Location patterns

Behavior and movement—mobility and patial memory

73, 78

 

Driving patterns and navigational efficiency

Executive function—reaction time and spatial memory

82, 83

 

Activity level

Movement—actigraphy

79, 84

Device use

PIN and password attempts, reminders use, and more

Executive function—memory

92

 

Number of apps used, frequency, use patterns

Executive function

85,86,87,88,– 89, 93,94,– 95

 

Behavioral disruptions, social circle size, frequency of interactions

Behavior—social interactions

49, 64,65,66,67,68,– 69, 71, 72, 74,75,76,– 77

ECG

Heart rate (HR) and heart rate variability (HRV)

ANS function—heart electric activity

 
 

System recovery metrics

 

36,37,38,– 39, 99

 

Sleep patterns, phases and efficiency

  
 

Electrical activity metrics

  

PPG

Heart rate (HR) and heart rate variability (HRV)

ANS function—systemic circulation

 
 

System recovery metrics

 

36,37,38,– 39, 99

 

Sleep patterns, phases and efficiency

  
 

Oxygen saturation (SpO2)

  

IR thermometer

Skin temperature

Metabolic activity and hormonal Cycle

 
  

Immune system health, Acute illness

 

Ballistocardiography*

Sleep patterns, sleep phases and efficiency

Sleep

34, 53,54,55,56,– 57, 100

Galvanic skin response

Skin electrical resistance

Behavior—emotional stress levels

 
  

ANS function—physical stress levels

 

Ambient light sensor

Light intensity at visible wavelength

ANS function—circadian rhythm

 
  

Environment

 

UV sensor

Light intensity at UV wavelength

Environment

 

Electromyogram (EMG)

Activity level

Movement—gross and fine motor

 
 

Tremor

ANS—neuromuscular system health

 
 

Seizures

  
  1. *Ballistocardiography data acquired using a mattress strip, a non wearable