Fig. 4
From: High-dimensional detection of imaging response to treatment in multiple sclerosis
Direction of association for four representative brain regions. This figure shows that, at the population level, and for two representative regions, namely the thalamus (blue solid line) and the posterior cingulate gyrus (red solid line), we consistently observe atrophy (volume decrease) in the pre-treatment period (t < 0) and stabilisation/recovery post-treatment (t > 0). For the degree of disconnection, and for two other representative regions, namely the gyrus rectus (cyan dashed line) and the supplementary motor cortex (light brown dashed line), the direction of association is the opposite (but clinically the same), namely an increase in the degree of disconnection in the pre-treatment period and stabilisation/recovery post-treatment
