Fig. 4: Dynamics of motor symptoms across the medication cycle.

a Time course of tremor severity from the left upper extremity (LUE) of one participant during the laboratory visit of study 3 (the value of 63% outlined in red in panel b was obtained from this time series). Tremor severity was obtained each time a prescribed motor task was performed (whether during one of the several scripted ADLs or the rest, gait and alternating hand movement tasks performed every 30 min). We considered each nonoverlapping 30-min interval during the visit, and excluded any period that did not contain multiple ratings (those periods highlighted red that have a gray dash above them). Among the remaining subset of eight 30-min intervals, we calculated the percentage of periods that contained at least two changes in symptom severity (marked with a green “O” above them). For example, in this participant, rapid fluctuations in symptom severity are apparent in the second, fourth, sixth, and ninth periods. The remaining periods did not contain more than two changes (marked with a red “X” above them). b All participants; the percent of 30-min periods during the lab portion of study 3 during which at least two changes to symptom severity occurred. The cell of the matrix representation that is highlighted in red shows the percentage number of instances of at least two changes in tremor severity within a 30-min period derived from the plot shown in panel a.