Table 3 Primary outcome domains and statistical significance (α ≤ 0.05) of the included studies (n = 56).
Core area | Outcome domain | Positive results | Neutral results | Negative results |
|---|---|---|---|---|
II. Clinical outcomes | 3. Cardiac outcomes | 3 | 0 | 0 |
5. Endocrine outcomes | 7 | 13 | 0 | |
9. General outcomes | 1 | 0 | 0 | |
14. Metabolism and nutrition outcomes | 1 | 0 | 0 | |
22. Respiratory, thoracic and mediastinal outcomes | 0 | 4 | 0 | |
III. Life impact | 25. Physical functioning | 2 | 5 | 0 |
28. Emotional functioning/wellbeing | 2 | 1 | 0 | |
29. Cognitive functioning | 1 | 0 | 0 | |
30. Global quality of life | 2 | 3 | 0 | |
32. Delivery of care | 5 | 2 | 0 | |
IV. Resource use | 34. Economic | 0 | 1 | 0 |
35. Hospital | 0 | 1 | 0 | |
27. Societal/care burden | 1 | 0 | 0 | |
V. Adverse events | 38. Adverse events/effects | 0 | 1 | 0 |
