Table 3 Secondary outcome analysis of DASH, SPADI, EQ5D5L, and NRS.

DASH

0.040

Baseline

61.50 ± 16.36

57.77 ± 16.03

0.234

6 weeks

43.08 ± 14.53

41.58 ± 13.08

0.575

12 weeks

21.42 ± 10.40

24.88 ± 14.44

0.158

24 weeks

11.08 ± 7.45

14.75 ± 11.75

0.057

Δbaseline-6weeks

−18.41 ± 17.46

−16.18 ± 17.29

0.506

Δbaseline-12weeks

−40.08 ± 16.73

−32.89 ± 20.72

0.050

Δbaseline-24weeks

−50.42 ± 15.87

−43.02 ± 19.28

0.031

SPADI

0.001

Baseline

92.36 ± 10.63

81.31 ± 19.67

0.001

6 weeks

53.31 ± 18.28

50.76 ± 15.29

0.434

12 weeks

26.90 ± 14.11

27.89 ± 15.98

0.734

24 weeks

11.94 ± 10.08

15.18 ± 12.66

0.145

Δbaseline-6weeks

−39.05 ± 21.93

-30.55 ± 18.78

0.033

Δbaseline-12weeks

−65.46 ± 17.12

−53.42 ± 22.87

0.003

Δbaseline-24weeks

−80.42 ± 13.19

−66.13 ± 22.50

<0.001

EQ5D5L

0.016

Baseline

0.479 ± 0.131

0.524 ± 0.157

0.105

6 weeks

0.699 ± 0.107

0.712 ± 0.126

0.567

12 weeks

0.802 ± 0.053

0.769 ± 0.103

0.039

24 weeks

0.833 ± 0.053

0.806 ± 0.091

0.067

Δbaseline-6weeks

0.221 ± 0.151

0.188 ± 0.171

0.297

Δbaseline-12weeks

0.324 ± 0.141

0.245 ± 0.177

0.012

Δbaseline-24weeks

0.354 ± 0.135

0.282 ± 0.166

0.015

NRS

0.878

Baseline

4.87 ± 2.54

5.13 ± 2.88

0.602

6 weeks

4.31 ± 1.97

4.47 ± 1.98

0.670

12 weeks

3.56 ± 1.98

3.53 ± 1.83

0.923

24 weeks

2.35 ± 1.88

2.25 ± 1.80

0.778

Δbaseline-6weeks

−0.56 ± 3.32

−0.66 ± 3.33

0.880

Δbaseline-12weeks

−1.31 ± 3.01

−1.60 ± 3.25

0.626

Δbaseline-24weeks

−2.53 ± 3.04

−2.89 ± 3.08

0.543