Fig. 7: Clusters of responsiveness to behavioral factors included in text messages.

Each color represents one of the three different patient groups identified from the exploratory k-means clustering analysis for the average pill bottle adherence measured over 6 months (primary outcome). These groups include: (1) Group 1 (Orange, n = 9) was the most adherent in response to observed feedback (“history”), (2) Group 2 (Yellow, n = 4) was the most adherent in response to social reinforcement or observed feedback, and (3) Group 3 (Blue, n = 16) was equally adherent in response to all types of messages. The error bars show the standard error for the cluster based on the underlying sample size (i.e., a threshold of ≥25 observations was applied).