Fig. 2: Progression patterns of the three PD subtypes within the PPMI cohort. | npj Digital Medicine

Fig. 2: Progression patterns of the three PD subtypes within the PPMI cohort.

From: Identification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data

Fig. 2

a Averaged progression trajectories in clinical manifestations by subtypes, with shading indicating standard error of the mean (SEM). b Sankey diagrams showing evolution patterns of motor phenotypes (tremor dominant, indeterminate, and PIGD) by subtypes. c Sankey diagrams showing evolution patterns of cognition phenotypes (normal cognition, MCI, and dementia) by subtypes. d Sankey diagrams showing evolution patterns of mood phenotypes (normal, mild depression, moderate depression, and severe depression) by subtypes. e Sankey diagrams showing evolution patterns of sleep phenotypes (REM sleep behavior disorder [RBD] negative and positive) by subtypes.

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