Table 1 Baseline demographic and clinical characteristics for the total sample and by A/T biomarker profile
Total sample (N = 167) | ||||||
|---|---|---|---|---|---|---|
A- T- (n = 106) | A + T- (n = 46) | A + T+ (n = 15) | P value | Post hoc group comparisons | ||
Age (M, SD) | 74.3 (7.5) | 73.0 (7.9) | 76.5 (6.9) | 76.4 (5.0) | 0.019 | A-T- < A + T-; A-T- < A + T+ |
Sex (n, %) | ||||||
F | 105 (62.9%) | 66 (62.3%) | 28 (60.9%) | 11 (73.3%) | 0.670 | N.S. |
M | 62 (37.1%) | 40 (37.7%) | 18 (39.1%) | 4 (26.7%) | ||
Years of education (M, SD) | 16.6 (2.47) | 16.7 (2.47) | 16.2 (2.61) | 16.7 (1.98) | 0.457 | N.S. |
Race (n, %) | ||||||
Asian | 5 (3.0%) | 4 (3.8%) | 1 (2.2%) | 0 (0%) | 0.96 | N.S. |
Black | 14 (8.4%) | 10 (9.4%) | 3 (6.5%) | 1 (6.7%) | ||
White | 146 (87.4%) | 90 (84.9%) | 42 (91.3%) | 14 (93.3%) | ||
Other | 2 (1.2%) | 2 (1.8%) | 0 (0%) | 0 (0%) | ||
Ethnicity (n, %) | ||||||
Hispanic | 1 (0.6%) | (0%) | 1 (2.2%) | 0 (0%) | 0.266 | N.S. |
Non-Hispanic | 166 (99.4%) | 106 (100%) | 45 (97.8%) | 15 (100%) | ||
CDR Global (n, %) | ||||||
0 | 152 (94.4%) | 96 (96.0%) | 37 (92.5%) | 19 (90.5%) | 0.414 | N.S. |
0.5 | 9 (5.6%) | 4 (4.0%) | 3 (7.5%) | 2 (9.5%) | ||
MMSE (M, SD) | 28.8 (1.4) | 28.9 (1.4) | 28.8 (1.9) | 28.3 (2.1) | 0.302 | N.S. |
Global amyloid burden DVR (M, SD) | 1.16 (0.19) | 1.07 (0.04) | 1.32 (0.21) | 1.37 (0.27) | <.001 | A-T- < A + T- < A + T+ |
Neocortical tau SUVR (M, SD) | 1.19 (0.09) | 1.16 (0.06) | 1.19 (0.06) | 1.39 (0.08) | <.001 | A-T- < A + T- < A + T+ |
Cortical thickness AD signature region (mm) (M, SD) | 2.86 (0.14) | 2.89 (0.12) | 2.82 (0.16) | 2.87 (0.17) | 0.012 | A-T- > A + T-; A + T- < A + /T+ |
MDLC (M, SD) | ||||||
BRANCH Composite | 0.58 (0.12) | 0.60 (0.11) | 0.55 (0.09) | 0.52 (0.15) | 0.009 | A-T- > A + T-; A-T- > A + T+ |
Digit Signs | 0.27 (0.10) | 0.29 (0.11) | 0.24 (0.08) | 0.23 (0.10) | 0.001 | A-T- > A + T-; A-T- > A + T+ |
Face Name | 0.79 (0.17) | 0.81 (0.16) | 0.76 (0.16) | 0.71 (0.23) | 0.073 | A-T- > A + T-; A-T- > A + T+ |
Groceries Prices | 0.67 (0.14) | 0.68 (0.14) | 0.65 (0.13) | 0.59 (0.15) | 0.046 | A-T- > A + T > A + T+ |
