Table 2 Summary of the clinical datasets used in this study

From: Multimodal machine learning enables AI chatbot to diagnose ophthalmic diseases and provide high-quality medical responses

 

Internal evaluation (n = 2292)

External evaluation (n = 2940)

Datasets

Dataset 1 (n = 1065)

Dataset 2 (n =189)

Dataset 3 (n = 57)

Dataset 4 (n = 813)

Dataset 5 (n = 168)

Dataset 6 (n = 1222)

Dataset 7 (n = 221)

Dataset 8 (n = 688)

Dataset 9 (n = 524)

Dataset 10 (n = 285)

Data providers

Researchers

Researchers

Researchers

Patients

Patients

Researchers

Researchers

Researchers

Patients

Patients

Model

 Unimodal model

Text

Text

Text

Text

Text

Text

Text

Text

Text

Text

 Multimodal model

NA

Text + slit-lamp

Text + smartphone

Text + smartphone

Text + slit-lamp + smartphone

NA

Text + slit-lamp

Text + smartphone

Text + smartphone

Text + slit-lamp + smartphone

Subspecialty, n (%)

 General outpatient clinic

358 (33.6%)

68 (36.0%)

4 (7.0%)

123 (15.1%)

22 (13.0%)

186 (15.2%)

20 (9.0%)

144 (20.9%)

142 (27.1%)

48 (16.8%)

 Cornea

201 (18.9%)

26 (13.8%)

16 (28.1%)

208 (25.6%)

28 (16.6%)

244 (20.0%)

38 (17.2%)

168 (24.4%)

114 (21.8%)

32 (11.2%)

 Cataract

123 (11.5%)

16 (8.5%)

4 (7.0%)

131 (16.1%)

34 (20.1%)

127 (10.4%)

39 (17.6%)

63 (9.2%)

62 (11.8%)

38 (13.3%)

 Optometry

85 (8.0%)

12 (6.3%)

21 (36.8%)

81 (10.0%)

25 (14.8%)

228 (18.7%)

51 (23.1%)

99 (14.4%)

71 (13.5%)

49 (17.2%)

 Glaucoma

120 (11.3%)

6 (3.2%)

2 (3.5%)

64 (7.9%)

10 (5.9%)

81 (6.6%)

27 (12.2%)

25 (3.6%)

31 (5.9%)

27 (9.5%)

 Retina

78 (7.3%)

20 (10.6%)

1 (1.8%)

76 (9.3%)

13 (7.7%)

99 (8.1%)

18 (8.1%)

90 (13.1%)

50 (9.5%)

29 (10.2%)

 Orbit

42 (3.9%)

29 (15.3%)

4 (7.0%)

69 (8.5%)

16 (9.5%)

145 (11.9%)

8 (3.6%)

42 (6.1%)

27 (5.2%)

18 (6.3%)

 Strabismus

20 (1.9%)

3 (1.6%)

3 (5.3%)

16 (2.0%)

7 (4.1%)

64 (5.2%)

10 (4.5%)

26 (3.8%)

11 (2.1%)

22 (7.7%)

 Emergency

27 (2.5%)

5 (2.6%)

2 (3.5%)

40 (4.9%)

7 (4.1%)

37 (3.0%)

5 (2.3%)

27 (3.9%)

12 (2.3%)

13 (4.6%)

 Neuro−ophthalmology

11 (1.0%)

4 (2.1%)

0

5 (0.6%)

6 (3.6%)

11 (0.9%)

5 (2.3%)

4 (0.6%)

4 (0.8%)

9 (3.2%)

Disease classification, n (%)

 Primary anterior segment diseases (cataract, keratitis, pterygium)a

153 (14.4%)

65 (34.4%)

9 (15.8%)

113 (13.9%)

32 (19.0%)

192 (15.7%)

61 (27.6%)

117 (17.0%)

75 (14.3%)

46 (16.1%)

 Other anterior segment diseases

289 (27.1%)

68 (36.0%)

15 (26.3%)

219 (26.9%)

64 (38.1%)

372 (30.4%)

81 (36.7%)

232 (33.7%)

140 (26.7%)

72 (25.3%)

 Vision disorders

318 (29.9%)

6 (3.2%)

14 (24.6%)

248 (30.5%)

31 (18.5%)

299 (24.5%)

8 (3.6%)

157 (22.8%)

140 (26.7%)

85 (29.8%)

 Intraorbital diseases and emergency

121 (11.4%)

27 (14.3%)

6 (10.5%)

89 (10.9%)

14 (8.3%)

94 (7.7%)

20 (9.0%)

46 (6.7%)

45 (8.6%)

31 (10.9%)

 Fundus and optic nerve disorders

121 (11.4%)

17 (9.0%)

7 (12.3%)

95 (11.7%)

21 (12.5%)

167 (13.7%)

26 (11.8%)

88 (12.8%)

76 (14.5%)

38 (13.3%)

 Eyelid diseases

63 (5.9%)

6 (3.2%)

6 (10.5%)

49 (6.0%)

6 (3.6%)

98 (8.0%)

25 (11.3%)

48 (7.0%)

48 (9.2%)

13 (4.6%)

Sex, n (%)

 Male

515 (48.4%)

90 (47.6%)

32 (56.1%)

373 (45.9%)

91 (54.2%)

600 (49.1%)

105 (47.5%)

337 (49.0%)

258 (49.2%)

129 (45.3%)

 Female

550 (51.6%)

99 (52.4%)

25 (43.9%)

440 (54.1%)

77 (45.8%)

622 (50.9%)

116 (52.5%)

351 (51.0%)

266 (50.8%)

156 (54.7%)

 Age (mean ± SD)

38.0 ± 24.5

53.1 ± 19.3

39.9 ± 26.0

37.6 ± 24.7

42.3 ± 18.0

40.8 ± 23.8

53.1 ± 18.9

43.1 ± 22.6

37.9 ± 24.9

41.5 ± 22.6

Laterality, n (%)

 Unilateral

427 (40.1%)

100 (52.9%)

22 (38.6%)

357 (43.9%)

74 (44.0%)

434 (35.5%)

107 (48.4%)

242 (35.2%)

186 (35.5%)

118 (41.4%)

 Bilateral

638 (59.9%)

89 (47.1%)

35 (61.4%)

456 (56.1%)

94 (56.0%)

788 (64.5%)

114 (51.6%)

446 (64.8%)

338 (64.5%)

167 (58.6%)

Visit type, n (%)b

 First visit

877 (82.3%)

131 (69.3%)

49 (86.0%)

656 (80.7%)

136 (81.0%)

995 (81.4%)

157 (71.0%)

553 (80.4%)

436 (83.2%)

235 (82.5%)

 Follow-up

188 (17.7%)

58 (30.7%)

8 (14.0%)

157 (19.3%)

32 (19.0%)

227 (18.6%)

64 (29.0%)

135 (19.6%)

88 (16.8%)

50 (17.5%)

  1. aDue to the critical role of cataract, keratitis, and pterygium in image model development, they are classified and analyzed separately.
  2. bThe ‘first visit’ category encompasses patients receiving their initial diagnosis, whereas the ‘follow-up’ category includes patients with a prior diagnosis.