Fig. 5: PRFE electrotherapy accelerates tissue regeneration and angiogenesis.
From: Smartphone administered pulsed radio frequency energy therapy for expedited cutaneous wound healing
a IR images of the temperature distribution at different stages. b Daily average temperature of all treatment and control wounds. c Digital images of Histological (hematoxylin and eosin staining (H&E)) assessment of wound tissues on Day 16 after wounding. The black box highlights the wound area, showcasing the distribution of scar tissue and the status of the epidermis and dermis. d Quantification comparison of the epidermal thickness of all treatment and control wounds (n = 10). e, f epidermal thickness (e) and scar area (f) for PRFE-C wound group, PRFE-L wound group, and the control wound group under two treatment modes. g, h Immunostaining images (g) and quantitative comparison (h) of CD31 and α-SMA from the tissue of all treatment and control wounds. (For two-tailed paired t-test, **** indicates P < 0.0001, *** indicates P < 0.001, ** indicates P < 0.01, * indicates P < 0.05, indicates P < 0.1, and ns indicates P > 0.1 (no significance)).
