Table 1 Clinicopathological characteristics of the patients in the institutional developmental, TCGA, and UCSF external validation sets

From: Interpretable multimodal transformer for prediction of molecular subtypes and grades in adult-type diffuse gliomas

Characteristics

Institutional set (n= 1053)

External validation set (n = 677)

P value

TCGA (n = 200)

UCSF (n = 477)

Age

54.9 ± 14.7

52.3 ± 14.9

56.8 ± 15.2

0.001

Sex

   

0.265

 Female

441 (41.9)

94 (47.0)

192 (40.3)

 

 Male

612 (58.1)

106 (53.0)

285 (59.7)

 

Molecular subtype

   

<0.001

 Oligodendroglioma

144 (13.7)

29 (14.5)

13 (2.7)

 

 IDH-mutant astrocytoma

157 (14.9)

57 (28.5)

90 (18.9)

 

 IDH-wildtype glioblastoma

752 (71.4)

114 (57.0)

374 (78.4)

 

Tumor grade

   

<0.001

 CNS WHO grade 2

164 (15.6)

44 (22.0)

46 (9.6)

 

 CNS WHO grade 3

109 (10.4)

58 (29.0)

29 (6.1)

 

 CNS WHO grade 4

780 (74.1)

98 (49.0)

402 (84.3)

 

MGMTp methylation status

   

<0.001

 Methylated

505 (48.0)

122 (61.0)

289 (60.6)

 

 Unmethylated

534 (50.7)

49 (24.5)

109 (22.8)

 

 Unknown

14 (1.3)

29 (14.5)

79 (16.6)

 
  1. Data are presented as mean ± standard deviation for continuous variables, or as number with percentage in parentheses for categorical variables. P values are based on comparisons between the institutional set, TCGA set, and UCSF set using one-way analysis of variance (ANOVA) for continuous variables and the chi-square test for categorical variables.
  2. CNS central nervous system, IDH isocitrate dehydrogenase; MGMTp O6-methylguanine-DNA methyltransferase promoter, TCGA Tumor Cancer Genome Atlas, UCSF The University of California, San Francisco, WHO World Health Organization.
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