Table 1 Patient characteristics in the train, valid, calibration, and test dataset

From: Conformal prediction enables disease course prediction and allows individualized diagnostic uncertainty in multiple sclerosis

 

Train dataset np = 9348; nv = 74,064

Valid dataset np = 719; nv = 5626

Calibration dataset np = 720; nv = 5771

Test dataset np=3595; nv = 28,323

Features

RRMS (np = 6414: nv = 48,393)

SPMSa (np = 2934: nv = 25,671)

RRMS (np = 491: nv = 3677)

SPMSb (np= = 228: nv = 1949)

RRMS (np = 467: nv = 3657)

SPMSc (np = 253: nv = 2114)

RRMS (np = 2451: nv = 18,525)

SPMSd (np = 1144: nv = 9798)

Female %

71.9

71.0

70.1

66.7

73.0

68.0

72.8

69.3

Age ± SD

40.4 ± 10.9

56.3 ± 10.8

39.9 ± 10.7

55.4 ± 10.5

40.8 ± 11.0

56.7 ± 10.8

40.6 ± 11.1

55.6 ± 10.6

EDSS ± SD

1.7 ± 1.2

5.6 ± 1.7

1.7 ± 1.2

5.4 ± 1.7

1.8 ± 1.2

5.4 ± 1.6

1.8 ± 1.2

5.7 ± 1.7

Disease duration ± SD

8.7 ± 7.0

21.9 ± 11.3

8.8 ± 7.2

21.2 ± 12.0

8.9 ± 6.9

21.5 ± 11.8

9.0 ± 7.4

21.8 ± 11.0

Debut relapse age ± SD

23.9 ± 16.8

27.1 ± 17.2

23.9 ± 16.3

26.1 ± 17.8

24.7 ± 16.3

28.1 ± 17.8

24.2 ± 16.8

25.5 ± 17.1

  1. Distributions of patients with diagnoses of RRMS and SPMS. Distributions are similar in all datasets (train, valid, calibration, and test). In this table, patients recorded to have a diagnosis of RRMS at the final hospital visit were categorized as RRMS. Patients with a diagnosis of SPMS were categorized as SPMS. In the SPMS patients, patients with SPMS at initial and final hospital visits (SPMS-SPMS) anp = 1696; nv = 10,542, bnp = 125; nv = 813, cnp = 152; nv = 904, dnp = 677; nv = 3977 and patients with RRMS at initial and SPMS at final hospital visits (RRMS-SPMS) anp = 1238; nv = 15,129, bnp = 103; nv = 1136, cnp = 101; nv = 1210, dnp = 467; nv = 5821. np = number of individual patients, nv = number of hospital visits.
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