Table 1 Study and patient characteristics of the included studies
Author | Year | Center | Magnification | Tile Size | Analysis | Reference standard | Patients/images/per set | No. of MSI patients/images | ||
|---|---|---|---|---|---|---|---|---|---|---|
Training | Internal validation | External validation | ||||||||
Hezi et al. | 2024 | Single | NR | NR | Patient-based | PCR | 260 | 100 | NR | Training:39 Internal validation:26 |
Gustav et al. | 2024 | Multiple | NR | 224*224 | Patient-based | PCR | 2039 | 2039 | 429 | Training:210 Internal validation:210 External validation:63 |
Tong et al. | 2023 | Single | NR | 256*256 | Patient-based | PCR/IHC | NR | 646 | 111 | Internal validation:323 External validation:54 |
Saillard et al. | 2023 | Multiple | 40* | 224*224 | Image-based | PCR/IHC | NR | NR | 1091 | External validation:169 |
Niehues et al. | 2023 | Multiple | 40* | 256*256 | Patient-based | PCR/IHC | NR | 2190 | 2448 | Internal alidation:245 External alidation:210 |
Guo et al. | 2023 | Multiple | 40* | 224*224 | Patient-based | PCR | NR | NR | 424 | External alidation:61 |
Gerwert et al. | 2023 | Single | NR | 256*256 | Patient-based | PCR/IHC | 331 | 147 | NR | Training:142 Internal validation:26 |
Chang et al. | 2023 | Multiple | 40* | 512*512 | Image-based | PCR | 1579 | 1579 | 305 | Training: Internal validation: External validation: |
Qiu et al. | 2022 | Single | NR | 224*224 | Image-based | PCR | 353 | 353 | NR | Training:63 Internal validation:63 |
Wu et al. | 2022 | Multiple | 20* | 512*512 | Patient-based | PCR/IHC | NR | 441 | 696 | Internal validation:77 External validation:127 |
Guo et al. | 2022 | Multiple | 20* | 512*512 | Image-based | PCR/IHC | 278 | 59 | NR | Training:236 Internal validation:49 |
Fujii et al. | 2022 | Single | 20* | 256*256 | Image-based | PCR | 575 | 295 | NR | Training:20 Internal validation:14 |
Echle et al. | 2022 | Multiple | 20* | 224*224 | Patient-based | PCR/IHC | 8343 | 9801 | Training:1020 External validation:1231 | |
Kather et al. | 2019 | Mutiple | NR | NR, NR | Patient-based | PCR | 1053 | NR | 378 | Training: NR External validation:28 |
Echle et al. | 2020 | Mutiple | 20* | 512*512 | Patient-based | PCR/IHC | 6046 | 6046 | 2302 | Training:744 Internal validation:744 External validation:321 |
Cao et al. | 2020 | Mutiple | 20* | 512*512 | Image-based | PCR | 429 | 429 | 785 | Training:71 Internal validation:71 External validation:164 |
Yamashita et al. | 2021 | Single | 40* | 256*256 | Patient-based | PCR | 100 | NR | 323 | Training:50 Internal validation: NR External validation:52 |
Krause et al. | 2021 | Single | 20* | 512*512 | Patient-based | PCR | NR | 142 | NR | Internal validation:21 |
Lee et al. | 2021 | Mutiple | 20* | 360*360 | Patient-based | PCR/IHC | NR | NR | 274 | External validation:149 |
