Fig. 5: Propensity score-matched analysis of subgroups with actual HR/SBP within 20% of personalized vs. population targets. | npj Digital Medicine

Fig. 5: Propensity score-matched analysis of subgroups with actual HR/SBP within 20% of personalized vs. population targets.

From: Personalized and real time hemodynamic management in critical care using Dynamic Cohort Ensemble Learning (DynaCEL)

Fig. 5

This analysis, based on the 18-hour MOP cohort from the MIMIC-IV dataset, compares two subgroups: patients whose actual HR and SBP values were within 20% of DynaCEL-predicted personalized targets and those within 20% of fixed population-based targets (HR = 80 bpm, SBP = 120 mmHg). a Illustrates the subgrouping strategy and highlights the overlapping cases, which were excluded from propensity score matching but retained in the mortality analysis. b Shows the distribution of overlap between the two subgroups, and c presents absolute mean differences in clinical characteristics before and after matching to assess covariate balance. Matching was performed using 1:1 nearest-neighbor matching between non-overlapping individuals, while overlapping cases were treated as self-matched. ICU intensive care unit, DynaCEL Dynamic Cohort Ensemble Learning, HR heart rate, SBP systolic blood pressure, MOP moment of prediction, MIMIC-IV Medical Information Mart for Intensive Care, COPD chronic obstructive pulmonary disease, MSLD moderate or severe liver disease, HIV/AIDS human immunodeficiency virus/acquired immunodeficiency syndrome, SOFA Sequential Organ Failure Assessment, MV mechanical ventilation.

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