Table 3 Demographic and radiologic factors of tricompartmental OA subclasses

From: Osteoarthritis progression pattern based on patient specific characteristics using machine learning

Variables

JSN-dominant OA (n = 43)

Indeterminate OA (n = 170)

O-dominant OA (n = 141)

P-value (post-hoc)

Initial visit

Final visit

JSN-dominant OA

Indeterminate OA

O-dominant OA

P-value (post-hoc)

JSN-dominant OA

Indeterminate OA

O-dominant OA

P-value (post-hoc)

Demographic factors

OARSI grade for radiographic factors

Age (years, initial visit)

61.8 ± 9.7

61.0 ± 7.6

59.5 ± 7.6

NS

 JSN (mean grade)

Age (years, final visit)

72.1 ± 9.3

72.0 ± 7.5

70.4 ± 7.3

NS

 MTF

0.7 ± 0.5

0.5 ± 0.6

0.7 ± 0.5

NS

2.6 ± 0.7

2.3 ± 0.8

1.4 ± 0.6

<0.001 (J > O)

Sex (male/female)

6/37

35/135

31/110

NS

 LTF

0.1 ± 0.4

0.1 ± 0.3

0.1 ± 0.3

NS

0.4 ± 0.9

0.2 ± 0.7

0.4 ± 0.7

NS

BMI (kg/m2)

25.1 ± 2.3

25.8 ± 3.7

25.6 ± 3.1

NS

 PF

0.3 ± 0.5

0.2 ± 0.4

0.1 ± 0.3

0.020 (J > O)

1.6 ± 0.9

1.3 ± 0.8

1.1 ± 0.6

<0.001 (J > O)

BMD (lowest T-score)

−2.4 ± 1.2

−2.0 ± 1.0

−1.8 ± 1.1

0.005 (J < I, O)

 Osteophyte (mean grade)

Metabolic disease

27 (62.8%)

122 (71.8%)

117 (83.0%)

0.010 (J < O)

 MF

0.6 ± 0.6

1.0 ± 0.7

0.8 ± 0.6

0.004 (J < I)

1.7 ± 0.5

2.4 ± 0.7

2.5 ± 0.6

<0.001 (J < I, O)

 HTN

24 (55.8%)

116 (68.2%)

105 (74.5%)

NS

 LF

0.2 ± 0.5

0.4 ± 0.5

0.3 ± 0.5

NS

1.5 ± 0.7

1.9 ± 0.7

2.0 ± 0.7

0.002 (J < I, O)

 DM

11 (25.6%)

61 (35.9%)

55 (39.0%)

NS

 MT

0.9 ± 0.4

0.7 ± 0.6

0.7 ± 0.6

0.007 (J > O)

1.7 ± 0.5

1.8 ± 0.6

1.8 ± 0.7

NS

Dyslipidemia

15 (34.9%)

86 (50.6%)

71 (50.4%)

NS

 LT

0.3 ± 0.5

0.3 ± 0.5

0.3 ± 0.5

NS

1.6 ± 0.6

1.8 ± 0.8

1.7 ± 0.9

NS

Other comorbidities

7 (16.3%)

55 (32.4%)

40 (28.4%)

NS

 PF

0.3 ± 0.5

0.6 ± 0.5

0.5 ± 0.5

0.015 (J < I)

1.8 ± 0.4

1.7 ± 0.6

1.7 ± 0.6

NS

Follow-up period (months)

10.3 ± 2.7

11.0 ± 2.8

10.9 ± 3.1

NS

         
  1. OA osteoarthritis, NS not significant, BMI body mass index, BMD bone mineral density, HTN hypertension, DM diabetes mellitus, OARSI Osteoarthritis Research Society International, JSN joint space narrowing, MTF medial tibiofemoral, LTF lateral tibiofemoral, PF patellofemoral, MF medial femoral condyle, LF lateral femoral condyle, MT medial tibial plateau, LT lateral tibial plateau, O-dominant osteophyte-dominant, JSN-dominant joint space narrowing-dominant, J JSN-dominant OA, I Indeterminate OA, O O-dominant OA.
Back to article page