Fig. 3: Dedifferentiated status significantly affects overall survival. | npj Digital Medicine

Fig. 3: Dedifferentiated status significantly affects overall survival.

From: Developing a thyroid cancer differentiation state classification system using deep residual networks and metabolic signature profiling

Fig. 3

Dedifferentiation status drives poor survival, with lipid metabolites adding prognostic insight beyond conventional clinicopathologic factors. a Univariate Cox regression of thyroid cancer patient prognosis FUSCC, indicating that age (>55 years), pathology type, ETE, ENE, DM, TNM and RR were independent prognostic factors for thyroid cancer, with p < 0.05. ETE extrathyroidal extension, ENE extranodal extension, DM distant metastasis, RR RAI refractoriness, CI confidence interval. b Multivariate Cox regression of thyroid cancer patient prognosis at FUSCC showing that differentiation status had the most significant impact among all the aforementioned factors. c Kaplan‒Meier curve showing that PDTC and ATC patients had poor prognoses. P values were calculated via the log-rank test. d Thyroid differentiation scores of different differentiation statuses. TDS scoring failed to differentiate between PDTC and ATC. e Multigroup volcano plots showing correlations between clinical phenotypes and metabolites analyzed by Benjamini‒Hochberg-corrected Mann‒Whitney U tests (q < 0.05, Log2 FC > 2 or Log2 FC < −2). ETE and LNM. No both had the strongest correlation with the metabolites (n = 7). f Spearman correlation analysis of clinical phenotypes and metabolites. Both (FDR < 0.05) PC (20:1_18:1) and PC (18:1_18:1) were related to age, metastasis, ETE and LNM number. 1-Methylnicotinamide was positively related to ENE.

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