Fig. 6: Metabolic reprogramming profiles of differentiated cells. | npj Digital Medicine

Fig. 6: Metabolic reprogramming profiles of differentiated cells.

From: Developing a thyroid cancer differentiation state classification system using deep residual networks and metabolic signature profiling

Fig. 6

Coordinated mRNA–metabolite analysis pinpoints a metabolic rewiring distinguishing dedifferentiated from well-differentiated thyroid carcinomas. a The mRNA expression of metabolic genes paired with the abundances of paired polar metabolites. Red points represent significant changes in both the metabolite and the mRNA. b The mRNA expression of metabolic genes paired with the abundances of paired lipid metabolites. Red points represent significant changes in both the metabolite and the mRNA. c The correlation network centered on NT5E and PNP between WDTC and DDTC. Squares represent metabolites, and circles represent mRNAs.

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