Fig. 6: Explanation of the Crabtree effect by energy metabolism.
From: Deep learning-based kcat prediction enables improved enzyme-constrained model reconstruction
a, HY and LY pathway definitions. PEP, phosphoenolpyruvate; PYR, pyruvate; OAA, oxaloacetate; CIT, citrate; ETC, electron transport chain. b, Model-inferred protein efficiency of energy metabolism in several common yeast species. Protein efficiency is the ATP produced per protein mass per unit time, in units of millimoles ATP per grams protein per hour. L. kluyveri, Lachancea kluyveri. c, Enzymes with significantly different kcat values between Crabtree positive and negative species. A two-sided Wilcoxon rank sum test was used to calculate P values. Crabtree positive species (n = 25) and Crabtree negative species (n = 77) were examined in this analysis. In the box plot, the central band represents the median value, the box represents the upper and lower quartiles and the whiskers extend up to 1.5 times the interquartile range beyond the box range.
