Fig. 1: Active site of Hmd and reactions catalysed by Hmd. | Nature Catalysis

Fig. 1: Active site of Hmd and reactions catalysed by Hmd.

From: Parahydrogen-enhanced magnetic resonance identification of intermediates in [Fe]-hydrogenase catalysis

Fig. 1

a, The FeGP cofactor (magenta) and methenyl-H4MPT+ substrate (green) in the closed active site. The proposed H2 binding site is highlighted in blue, and the hydride acceptor C14a is marked in methenyl-H4MPT+. His14 and Glu207 mark the start of the putative proton relay network29, highlighted in light blue. b, Methenyl-H4MPT+ reduction reaction, catalysed by Hmd with hydride transfer20,32. For methenyl-H4MPT+ and methylene-H4MPT, only the imidazolinium and imidazolidine rings are depicted. c, Hydrogen/deuteron isotope exchange reaction, catalysed by Hmd33.

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