Fig. 5 | Communications Biology

Fig. 5

From: Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin

Fig. 5

Model of the regulatory mechanism of OMD for generating uniform fibrils. OMD repeatedly binds and dissociates to type-I collagen during fibril formation in vitro. At first, OMD electrostatically binds to collagen. The driving force of the interaction is the favorable entropy caused by dehydration. After that, OMD dissociates from collagen, and then, collagen assembles itself. This phenomenon leads to a decrease the rate of fibril formation, and as a result, uniform fibrils are formed

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