Fig. 4 | Communications Biology

Fig. 4

From: Multiple claudin–claudin cis interfaces are required for tight junction strand formation and inherent flexibility

Fig. 4

Three candidate cis interfaces obtained by in silico mCldn15 protein–protein docking modeling. a Top views of the three main mCldn15 dimer poses obtained by “blind” protein–protein docking are shown in cartoon representation and labeled as Cis-1 (blue and purple), Cis-2 (blue and red), and Cis-3 (green and blue). The different interfaces were structurally superimposed using the blue monomer as a reference point. b Time-course plot of the RMSD values for Cis-1 (purple), Cis-2 (red), Cis-3 (green), and X-1 (black) dimers over 100 ns molecular dynamics simulations. c Side views for Cis-1, Cis-2, and Cis-3 interfaces with their corresponding calculated interface area (∆SASA) and binding energy (Ebind)

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