Fig. 2 | Communications Biology

Fig. 2

From: Sea turtle fibropapilloma tumors share genomic drivers and therapeutic vulnerabilities with human cancers

Fig. 2

Differentially expressed host (C. mydas) and viral (ChHV5) transcripts. a Top ten statistically significant upregulated and top ten downregulated transcripts in fibropapillomatosis tumors compared with control tissue. Transcript expression values underlying the differential expression analysis are provided in Supplementary Table 4. Differential expression p-values reported are adjusted p-values, generated by DESeq2 by a Wald test followed by Benjamini–Hochberg correction. b Relative expression of Fndc1 mRNA in fibropapillomatosis tumor and control samples, as detected by RT-qPCR. Data for 66 tumor samples and 14 control samples. The p-value was calculated by t-test. c Expression levels (trimmed mean of M values, TMM) of ChHV5 viral RNA de novo transcripts across the ten RNA-seq samples. Related transcript variants are denoted by t.1, t.2, or t.3

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