Fig. 4 | Communications Biology

Fig. 4

From: Sea turtle fibropapilloma tumors share genomic drivers and therapeutic vulnerabilities with human cancers

Fig. 4

Pathway, disease gene ontology (GO) term, and transcriptional regulator analysis of the top 600 transcripts differentially expressed in fibropapillomatosis tumors. a Top 50 canonical pathways of the fibropapillomatosis tumor differentially expressed transcripts (RNA-seq), as detected by IPA, ranked by p-value (calculated by right-tailed Fisher’s Exact Test, with Benjamini–Hochberg correction). b Activation/inhibition z-scores of the canonical pathways of the fibropapillomatosis tumor differentially expressed transcripts, as detected by IPA. c Activation z-scores of the top 25 disease-associated GO terms of the fibropapillomatosis tumor differentially expressed transcripts (RNA-seq), as detected by IPA, ranked by p-value (calculated by right-tailed Fisher’s Exact Test, with Benjamini–Hochberg correction). d Activation/inhibition z-scores of the inferred transcriptional regulators (ITRs) of the fibropapillomatosis tumor differentially expressed transcripts (RNA-seq), as detected by IPA, ranked by p-value (calculated by right-tailed Fisher’s Exact Test, with Benjamini–Hochberg correction). Legend of x-axis labels for Fig. 3a–c is also provided in Supplementary Table 5

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