Fig. 4
The conformational properties of the variable regions of MSP214–34 are weakly perturbed by interaction with 6D8. a [15N-1H]-HSQC spectra of 3D7 MSP214–34 (red) and FC27 MSP214–34 (blue) in complex with 6D8 scFv. Assigned peaks are labelled and weak, unassigned peaks attributed to the structurally defined conserved residues are marked with asterisks. b Secondary Cα-Cβ chemical shifts for the variable residues of 3D7 MSP214–34 free (open bars) and in complex with 6D8 scFv (closed bars). c Secondary Cα-Cβ chemical shifts for the variable residues of FC27 MSP214–34 free (open bars) and in complex with 6D8 scFv (closed bars)
