Fig. 7 | Communications Biology

Fig. 7

From: Acquisition of resistance to carbapenem and macrolide-mediated quorum sensing inhibition by Pseudomonas aeruginosa via ICETn43716385

Fig. 7

The effect of azithromycin (AZM) treatment on PAO1 and PAO1/pUCP18::msr(E) in an in vivo murine infection model. The silicone implants pre-incubated with PAO1 and PAO1/pUCP18::msr(E) were inserted into the peritoneal cavity of mice by surgery. AZM treatment at 10 mg per mouse significantly reduced the PAO1 CFU recovered from the silicone implants by 2.0-log (a) and the PAO1 CFU recovered from the mouse spleens by 3.8-log (b), whereas such reduction was not observed in PAO1/pUCP18::msr(E) recovered either from the silicone implants (a) or the mice spleens (b). Results are shown as log CFU per silicone implant and log CFU per mouse spleen, respectively (n = 6; **P < 0.01; ns P > 0.05; Mann–Whitney test, two-sided)

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