Fig. 1 | Communications Biology

Fig. 1

From: Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions

Fig. 1

Schematic showing the structure of Fc hexamers. Fc hexamers consist of the human IgG Fc hinge-CH2-CH3 domains fused to an IgM tailpiece domain, which provides stable hexamerization. Fc-γ receptor (blue cylindar), C1q (orange oval), and FcRn (purple crescent)-binding sites and L309C mutation generating an additional cysteine bond (red) are indicated. Adapted from Qureshi et al.22

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