Fig. 7 | Communications Biology

Fig. 7

From: Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells

Fig. 7

Schematic diagram of the maintenance of RAD51 by the BMP9–ALK-1/BMPR2 signaling axis. In healthy individuals, RAD51 is maintained in the pulmonary endothelium as the BMP9–ALK-1/BMPR2 signaling axis downregulates miR-96 expression and prevents the destabilization of RAD51 mRNA. When the BMP9–ALK-1/BMPR2 signaling axis is deregulated, elevation of miR-96 leads to attenuation of RAD51. As a result, DNA damage accumulates in the pulmonary endothelium over several decades causing endothelial injury and dysfunction, and eventually triggers pulmonary vascular remodeling

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