Fig. 2
From: Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors
Fluctuations in the pore diameter of the nAChR during simulation. a Fluctuations in the pore profile of wild-type nAChR in presence of water (black), ethanol (pink), and acetylcholine (blue) are presented as averages over final 10 ns (shades indicate SEM). Pore diameter in the ligand free remains robust, whereas 200 μM ACh induces considerable fluctuations and increases along the channel. A total of 25 mM of ethanol induces diverse fluctuations in extracellular and transmembrane domain. b The pore of the αD83K mutant remains unchanged in the presence of ethanol. In the ligand-free, as well as ACh simulations pore profiles are comparable with WT. However, ethanol-induced fluctuations in the extracellular and transmembrane domains are marginal in comparison to WT receptor
