Fig. 7

Contact interactions between parasitized erythrocytes and human dermal microvascular endothelial cells. a Representative examples of simulated contact footprints that parasitized HbAA and HbAS erythrocytes at the trophozoite and schizont stage leave on the substratum. For simulation parameters see Fig. 5 legend, except that, for comparative reasons, a spherical shape with a reduced volume of 0.99 was used for both parasitized HbAA and HbAS erythrocytes at the schizont stage. b Representative simulated adhesive patches are shown for parasitized HbAA and HbAS erythrocytes at the trophozoite and schizont stage. The color code indicates the relative number of productive cytoadhesive interactions between the parasitized erythrocyte and the substratum at a particular point in time. The cells are viewed from the side facing the substratum. c Experimentally determined adhesive contact maps of trophozoites and schizonts. The adhesive contact maps were obtained by projecting the amplitude profiles derived from the flow chamber experiments around the circumference of the cells, yielding an average dwell time per unit angle as an indicator of contact points between the cell and the substratum at a given spatial and temporal position