Fig. 5 | Communications Biology

Fig. 5

From: Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates

Fig. 5

Antimicrobial activity of second-generation library of synthetic peptides. a In vitro activity of Pol-CP-NH2 and second-generation of analogs against Gram-positive bacteria (Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis and Bacillus megaterium), Fungi (Candida albicans and Candida tropicalis) and Gram-negative bacteria (Escherichia coli, Enterobacter cloacae and Serratia marcescens). Assays were performed in three independent replicates and heat map OD600 values are the arithmetic mean of the replicates in each condition. b MIC (µmol L−1) average vs. fH in TFE/Water solution. c Graph correlating MIC (μmol L−1) averages vs. H and d MIC (μmol L−1) averages vs. μH, where blue boxes represent peptides with lower activity and red boxes show peptides with higher activity compared to the wild-type, in which we can observe ranges of optimal activity in determined intervals of H and μH values

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