Fig. 3 | Communications Biology

Fig. 3

From: Global analysis of tRNA and translation factor expression reveals a dynamic landscape of translational regulation in human cancers

Fig. 3

Differential expression of tRNAs at codon level and functional consequences. a Differentially expressed tRNAs at codon level across different cancer types. Magenta denotes up-regulation; cyan denotes down-regulation. Color bar in the left panel denotes the number of cancer types with differentially expressed codons. X-axis represents 15 cancer types with > 5 tumor-normal paired miRNA-seq samples and y-axis is tRNA at the codon level (middle panel). Circles denote tRNAs with expression alterations. The boxplot (right panel) shows the comparison of codon O/E ratio between up-regulated codons and down-regulated codons (Student’s t test, p = 0.047; Wilcoxon's test, p = 0.043; bootstrap test, p = 0.017). b Survival curves for KIRC patients with two up-regulated codons and two down-regulated codons. Red and blue curves denote patients with high and low tRNA expression, respectively. The log-rank test was used to examine the association between tRNA expression at the codon level and patient survival

Back to article page